ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system

We have developed an in vitro mRNA stability system using HeLa cell cytoplasmic S100 extracts and exogenous polyadenylated RNA substrates that reproduces regulated aspects of mRNA decay. The addition of cold poly(A) competitor RNA activated both a sequence-specific deadenylase activity in the extrac...

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Detalhes bibliográficos

Publicado no:	Genes Dev
Principais autores:	Ford, Lance P., Watson, Janice, Keene, Jack D., Wilusz, Jeffrey
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Cold Spring Harbor Laboratory Press 1999
Assuntos:	Research Paper
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316394/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9925643/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.2.188
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