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ATR disruption leads to chromosomal fragmentation and early embryonic lethality
Although a small decrease in survival and increase in tumor incidence was observed in ATR(+/−) mice, ATR(−/−) embryos die early in development, subsequent to the blastocyst stage and prior to 7.5 days p.c. In culture, ATR(−/−) blastocysts cells continue to cycle into mitosis for 2 days but subsequen...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2000
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC316378/ https://ncbi.nlm.nih.gov/pubmed/10691732 |
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