Pentoxifylline Attenuates Transforming Growth Factor- β1-Stimulated Elastogenesis in Human Tunica Albuginea-Derived Fibroblasts Part 2: Interference in a TGF- β1/Smad-Dependent Mechanism and Downregulation of AAT1

INTRODUCTION: TGF-β1 works through Smad dependent mechanisms and contributes to the pathogenesis of Peyronie’s Disease (PD). Pentoxyfylline (PTX) antagonizes the effects of TGF-β1 and has been utilized for the management of PD although the mechanisms of action are not entirely clear. AIM: We studied...

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Autores principales: Lin, Guiting, Shindel, Alan, Banie, Lia, Ning, HongXiu, Lin, Ching-Shwun, Lue, Tom
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163605/
https://ncbi.nlm.nih.gov/pubmed/20384945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1743-6109.2010.01749.x
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