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Targeted Vault Nanoparticles Engineered with an Endosomolytic Peptide Deliver Biomolecules to the Cytoplasm

Vault nanoparticles were engineered to enhance their escape from the endosomal compartment by fusing a membrane lytic peptide derived from adenovirus protein VI (pVI) to the N-terminus of the major vault protein to form pVI-vaults. We demonstrate that these pVI-vaults disrupt the endosomal membrane...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Han, Muri, Kickhoefer, Valerie A., Nemerow, Glen R., Rome, Leonard H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163598/
https://ncbi.nlm.nih.gov/pubmed/21740042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nn2014613
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