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Impact of autoclave sterilization on the activity and structure of formulated heparin

The stability of a formulated heparin was examined during its sterilization by autoclaving. A new method to follow loss in heparin binding to the serine protease inhibitor, antithrombin III, and the serine protease, thrombin, and was developed using a surface plasmon resonance (SPR) competitive bind...

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Detalhes bibliográficos
Main Authors: Beaudet, Julie M., Weyers, Amanda, Solakyildirim, Kemal, Yang, Bo, Takieddin, Majde, Mousa, Shaker, Zhang, Fuming, Linhardt, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163591/
https://ncbi.nlm.nih.gov/pubmed/21416466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.22527
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