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Proofreading deficiency of Pol I increases the levels of spontaneous rpoB mutations in E. coli

The fidelity role of DNA polymerase I in chromosomal DNA replication in E. coli was investigated using the rpoB forward target. These experiments indicated that in a strain carrying a proofreading-exonuclease-defective form of Pol I (polAexo mutant) the frequency of rpoB mutations increased by about...

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Bibliografiske detaljer
Main Authors: Makiela-Dzbenska, K., Jonczyk, P., Schaaper, R.M., Fijalkowska, I.J.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163159/
https://ncbi.nlm.nih.gov/pubmed/21459099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2011.03.011
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