Effects of strong CYP2D6 and 3A4 inhibitors, paroxetine and ketoconazole, on the pharmacokinetics and cardiovascular safety of tamsulosin

AIM: To determine the effect of the strong CYP2D6 inhibitor paroxetine and strong CYP3A4 inhibitor ketoconazole on the pharmacokinetics and safety (orthostatic challenge) of tamsulosin. METHODS: Two open-label, randomized, two-way crossover studies were conducted in healthy male volunteers (extensiv...

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Bibliografiska uppgifter
Huvudupphovsmän: Troost, Joachim, Tatami, Shinji, Tsuda, Yasuhiro, Mattheus, Michaela, Mehlburger, Ludwig, Wein, Martina, Michel, Martin C
Materialtyp: Artigo
Språk:Inglês
Publicerad: Blackwell Science Inc 2011
Ämnen:
Uropharmacology Themed Section
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162654/
https://ncbi.nlm.nih.gov/pubmed/21496064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.03988.x
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