DLK1-DIO3 Genomic Imprinted MicroRNA Cluster at 14q32.2 Defines a Stemlike Subtype of Hepatocellular Carcinoma Associated with Poor Survival

Hepatocellular carcinoma (HCC) is a heterogeneous and highly aggressive malignancy, for which there are no effective cures. Identification of a malignant stemlike subtype of HCC may offer patients with a dismal prognosis a potential targeted therapy using c-MET and Wnt pathway inhibitors. MicroRNAs...

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Main Authors: Luk, John M., Burchard, Julja, Zhang, Chunsheng, Liu, Angela M., Wong, Kwong F., Shek, Felix H., Lee, Nikki P., Fan, Sheung Tat, Poon, Ronnie T., Ivanovska, Irena, Philippar, Ulrike, Cleary, Michele A., Buser, Carolyn A., Shaw, Peter M., Lee, Chuen-Neng, Tenen, Daniel G., Dai, Hongyue, Mao, Mao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162431/
https://ncbi.nlm.nih.gov/pubmed/21737452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.229831
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