Sirtuin 1 (SIRT1) Deacetylase Activity Is Not Required for Mitochondrial Biogenesis or Peroxisome Proliferator-activated Receptor-γ Coactivator-1α (PGC-1α) Deacetylation following Endurance Exercise

The protein deacetylase, sirtuin 1 (SIRT1), is a proposed master regulator of exercise-induced mitochondrial biogenesis in skeletal muscle, primarily via its ability to deacetylate and activate peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). To investigate regulation of mitocho...

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Detalhes bibliográficos
Main Authors: Philp, Andrew, Chen, Ai, Lan, Debin, Meyer, Gretchen A., Murphy, Anne N., Knapp, Amy E., Olfert, I. Mark, McCurdy, Carrie E., Marcotte, George R., Hogan, Michael C., Baar, Keith, Schenk, Simon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162416/
https://ncbi.nlm.nih.gov/pubmed/21757760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.261685
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