Substrate Specificity of Lymphoid-specific Tyrosine Phosphatase (Lyp) and Identification of Src Kinase-associated Protein of 55 kDa Homolog (SKAP-HOM) as a Lyp Substrate

A missense single-nucleotide polymorphism in the gene encoding the lymphoid-specific tyrosine phosphatase (Lyp) has been identified as a causal factor in a wide spectrum of autoimmune diseases. Interestingly, the autoimmune-predisposing variant of Lyp appears to represent a gain-of-function mutation...

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Main Authors: Yu, Xiao, Chen, Ming, Zhang, Sheng, Yu, Zhi-Hong, Sun, Jin-Peng, Wang, Lina, Liu, Sijiu, Imasaki, Tsuyoshi, Takagi, Yuichiro, Zhang, Zhong-Yin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162412/
https://ncbi.nlm.nih.gov/pubmed/21719704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.254722
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