Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia

Relapse of drug-resistant acute lymphoblastic leukemia (ALL) has been associated with increased expression of survivin/BIRC5, an inhibitor of apoptosis protein, suggesting a survival advantage for ALL cells. In the present study, we report that inhibition of survivin in patient-derived ALL can eradi...

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Bibliographic Details
Main Authors: Park, Eugene, Gang, Eun Ji, Hsieh, Yao-Te, Schaefer, Paul, Chae, Sanna, Klemm, Lars, Huantes, Sandra, Loh, Mignon, Conway, Edward M., Kang, Eun-Suk, Hoe Koo, Hong, Hofmann, Wolf-Karsten, Heisterkamp, Nora, Pelus, Louis, Keerthivasan, Ganesan, Crispino, John, Kahn, Michael, Müschen, Markus, Kim, Yong-Mi
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2011
Subjects:
Lymphoid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162353/
https://ncbi.nlm.nih.gov/pubmed/21715311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-351239
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