Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy

Bone marrow (BM) provides chemoprotection for acute lymphoblastic leukemia (ALL) cells, contributing to lack of efficacy of current therapies. Integrin alpha4 (alpha4) mediates stromal adhesion of normal and malignant B-cell precursors, and according to gene expression analyses from 207 children wit...

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Main Authors: Hsieh, Yao-Te, Gang, Eun Ji, Geng, Huimin, Park, Eugene, Huantes, Sandra, Chudziak, Doreen, Dauber, Katrin, Schaefer, Paul, Scharman, Carlton, Shimada, Hiroyuki, Shojaee, Seyedmehdi, Klemm, Lars, Parameswaran, Reshmi, Loh, Mignon, Kang, Eun-Suk, Koo, Hong Hoe, Hofmann, Wolf-Karsten, Andrade, Jacob, Crooks, Gay M., Willman, Cheryl L., Müschen, Markus, Papayannopoulou, Thalia, Heisterkamp, Nora, Bönig, Halvard, Kim, Yong-Mi
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2013
Assuntos:
Lymphoid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591800/
https://ncbi.nlm.nih.gov/pubmed/23319569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-406272
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