Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy

Bone marrow (BM) provides chemoprotection for acute lymphoblastic leukemia (ALL) cells, contributing to lack of efficacy of current therapies. Integrin alpha4 (alpha4) mediates stromal adhesion of normal and malignant B-cell precursors, and according to gene expression analyses from 207 children wit...

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Bibliografski detalji
Glavni autori: Hsieh, Yao-Te, Gang, Eun Ji, Geng, Huimin, Park, Eugene, Huantes, Sandra, Chudziak, Doreen, Dauber, Katrin, Schaefer, Paul, Scharman, Carlton, Shimada, Hiroyuki, Shojaee, Seyedmehdi, Klemm, Lars, Parameswaran, Reshmi, Loh, Mignon, Kang, Eun-Suk, Koo, Hong Hoe, Hofmann, Wolf-Karsten, Andrade, Jacob, Crooks, Gay M., Willman, Cheryl L., Müschen, Markus, Papayannopoulou, Thalia, Heisterkamp, Nora, Bönig, Halvard, Kim, Yong-Mi
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2013
Teme:
Lymphoid Neoplasia
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591800/
https://ncbi.nlm.nih.gov/pubmed/23319569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-406272
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