miR-143 Overexpression Impairs Growth of Human Colon Carcinoma Xenografts in Mice with Induction of Apoptosis and Inhibition of Proliferation

BACKGROUND: MicroRNAs (miRNAs) are aberrantly expressed in human cancer and involved in the (dys)regulation of cell survival, proliferation, differentiation and death. Specifically, miRNA-143 (miR-143) is down-regulated in human colon cancer. In the present study, we evaluated the role of miR-143 ov...

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Главные авторы: Borralho, Pedro M., Simões, André E. S., Gomes, Sofia E., Lima, Raquel T., Carvalho, Tânia, Ferreira, Duarte M. S., Vasconcelos, Maria H., Castro, Rui E., Rodrigues, Cecília M. P.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2011
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162002/
https://ncbi.nlm.nih.gov/pubmed/21901135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023787
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