ACE as a Mechanosensor to Shear Stress Influences the Control of Its Own Regulation via Phosphorylation of Cytoplasmic Ser(1270)

OBJECTIVES: We tested whether angiotensin converting enzyme (ACE) and phosphorylation of Ser(1270) are involved in shear-stress (SS)-induced downregulation of the enzyme. METHODS AND RESULTS: Western blotting analysis showed that SS (18 h, 15 dyn/cm(2)) decreases ACE expression and phosphorylation a...

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Bibliografiske detaljer
Main Authors: Barauna, Valerio Garrone, Campos, Luciene Cristina Gastalho, Miyakawa, Ayumi Aurea, Krieger, Jose Eduardo
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161988/
https://ncbi.nlm.nih.gov/pubmed/21901117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022803
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