Mutations in fam20b and xylt1 Reveal That Cartilage Matrix Controls Timing of Endochondral Ossification by Inhibiting Chondrocyte Maturation

Differentiating cells interact with their extracellular environment over time. Chondrocytes embed themselves in a proteoglycan (PG)-rich matrix, then undergo a developmental transition, termed “maturation,” when they express ihh to induce bone in the overlying tissue, the perichondrium. Here, we ask...

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Autori principali: Eames, B. Frank, Yan, Yi-Lin, Swartz, Mary E., Levic, Daniel S., Knapik, Ela W., Postlethwait, John H., Kimmel, Charles B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161922/
https://ncbi.nlm.nih.gov/pubmed/21901110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002246
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