Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta)

BACKGROUND: Tafenoquine is an 8-aminoquinoline being developed for radical cure (blood and liver stage elimination) of Plasmodium vivax. During monotherapy treatment, the compound exhibits slow parasite and fever clearance times, and toxicity in glucose-6-phosphate dehydrogenase (G6PD) deficiency is...

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Bibliografiska uppgifter
Huvudupphovsmän: Dow, Geoffrey S, Gettayacamin, Montip, Hansukjariya, Pranee, Imerbsin, Rawiwan, Komcharoen, Srawuth, Sattabongkot, Jetsumon, Kyle, Dennis, Milhous, Wilbur, Cozens, Simon, Kenworthy, David, Miller, Anne, Veazey, Jim, Ohrt, Colin
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2011
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161915/
https://ncbi.nlm.nih.gov/pubmed/21801400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-10-212
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