Icaritin Shows Potent Anti-Leukemia Activity on Chronic Myeloid Leukemia In Vitro and In Vivo by Regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT Signalings

PURPOSE: To explore the effects of Icaritin on chronic myeloid leukemia (CML) cells and underlying mechanisms. METHOD: CML cells were incubated with various concentration of Icaritin for 48 hours, the cell proliferation was analyzed by MTT and the apoptosis was assessed with Annexin V and Hoechst 33...

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Autors principals: Zhu, Jian feng, Li, Zi jian, Zhang, Guang sen, Meng, Kun, Kuang, Wen yong, Li, Jin, Zhou, Xin fu, Li, Rui juan, Peng, Hong ling, Dai, Chong wen, Shen, Jian Kai, Gong, Fan jie, Xu, Yun xiao, Liu, Su fang
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161749/
https://ncbi.nlm.nih.gov/pubmed/21887305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023720
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