Icaritin Shows Potent Anti-Leukemia Activity on Chronic Myeloid Leukemia In Vitro and In Vivo by Regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT Signalings

PURPOSE: To explore the effects of Icaritin on chronic myeloid leukemia (CML) cells and underlying mechanisms. METHOD: CML cells were incubated with various concentration of Icaritin for 48 hours, the cell proliferation was analyzed by MTT and the apoptosis was assessed with Annexin V and Hoechst 33...

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Detalhes bibliográficos
Main Authors: Zhu, Jian feng, Li, Zi jian, Zhang, Guang sen, Meng, Kun, Kuang, Wen yong, Li, Jin, Zhou, Xin fu, Li, Rui juan, Peng, Hong ling, Dai, Chong wen, Shen, Jian Kai, Gong, Fan jie, Xu, Yun xiao, Liu, Su fang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161749/
https://ncbi.nlm.nih.gov/pubmed/21887305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023720
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