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Synthesis and PET studies of [(11)C-cyano]letrozole (Femara(®)), an aromatase inhibitor drug
INTRODUCTION: Aromatase, a member of the cytochrome P450 family, converts androgens such as androstenedione and testosterone to estrone and estradiol respectively. Letrozole (1-[bis-(4-cyanophenyl)methyl]-1H-1,2,4-triazole, Femara(®)) is a high affinity aromatase inhibitor (K(i)=11.5 nM) which has F...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3161428/ https://ncbi.nlm.nih.gov/pubmed/19217534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2008.11.010 |
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