Critical Role of c-Myc in Acute Myeloid Leukemia Involving Direct Regulation of miR-26a and Histone Methyltransferase EZH2

Increased expression or aberrant activation of c-Myc plays an important role in leukemogenesis. Here, we show that in acute myeloid leukemia (AML), c-Myc directly controls the expression of EZH2, a component of the Polycomb repressive complex 2, and miR-26a. miR-26a is downregulated in primary blast...

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Bibliografiske detaljer
Main Authors: Salvatori, Beatrice, Iosue, Ilaria, Djodji Damas, Nkerorema, Mangiavacchi, Arianna, Chiaretti, Sabina, Messina, Monica, Padula, Fabrizio, Guarini, Anna, Bozzoni, Irene, Fazi, Francesco, Fatica, Alessandro
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2011
Fag:
Short Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161419/
https://ncbi.nlm.nih.gov/pubmed/21901171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601911416357
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