Do consanguineous parents of a child affected by an autosomal recessive disease have more DNA identical-by-descent than similarly-related parents with healthy offspring? Design of a case-control study

BACKGROUND: The offspring of consanguineous relations have an increased risk of congenital/genetic disorders and early mortality. Consanguineous couples and their offspring account for approximately 10% of the global population. The increased risk for congenital/genetic disorders is most marked for...

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Detalhes bibliográficos
Main Authors: Teeuw, Marieke E, Henneman, Lidewij, Bochdanovits, Zoltan, Heutink, Peter, Kuik, Dirk J, Cornel, Martina C, ten Kate, Leo P
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Study Protocol
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161348/
https://ncbi.nlm.nih.gov/pubmed/20637082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-11-113
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