Ganglioside GM1 Deficiency in Effector T Cells From NOD Mice Induces Resistance to Regulatory T-Cell Suppression

OBJECTIVE: To detect GM1 deficiency and determine its role in effector T cells (Teffs) from NOD mice in establishing resistance to regulatory T-cell (Treg) suppression. RESEARCH DESIGN AND METHODS: CD4(+) and CD8(+) Teffs were isolated from spleens of prediabetic NOD mice for comparison with similar...

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Bibliographic Details
Main Authors: Wu, Gusheng, Lu, Zi-Hua, Gabius, Hans-Joachim, Ledeen, Robert W., Bleich, David
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2011
Subjects:
Immunology and Transplantation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161337/
https://ncbi.nlm.nih.gov/pubmed/21788572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1309
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