Immunosuppressive Effects of Streptozotocin-Induced Diabetes Result in Absolute Lymphopenia and a Relative Increase of T Regulatory Cells

OBJECTIVE: Streptozotocin (STZ) is the most widely used diabetogenic agent in animal models of islet transplantation. However, the immunomodifying effects of STZ and the ensuing hyperglycemia on lymphocyte subsets, particularly on T regulatory cells (Tregs), remain poorly understood. RESEARCH DESIGN...

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Bibliographic Details
Main Authors: Muller, Yannick D., Golshayan, Déla, Ehirchiou, Driss, Wyss, Jean Christophe, Giovannoni, Laurianne, Meier, Raphael, Serre-Beinier, Véronique, Puga Yung, Gisella, Morel, Philippe, Bühler, Leo H., Seebach, Jörg D.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2011
Subjects:
Immunology and Transplantation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161310/
https://ncbi.nlm.nih.gov/pubmed/21752956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0159
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