Anti-CD154 mAb and Rapamycin Induce T Regulatory Cell Mediated Tolerance in Rat-to-Mouse Islet Transplantation

BACKGROUND: Anti-CD154 (MR1) monoclonal antibody (mAb) and rapamycin (RAPA) treatment both improve survival of rat-to-mouse islet xenograft. The present study investigated the effect of combined RAPA/MR1 treatment on rat-to-mouse islet xenograft survival and analyzed the role of CD4(+)CD25(+)Foxp3(+...

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Bibliographic Details
Main Authors: Muller, Yannick D., Mai, Gang, Morel, Philippe, Serre-Beinier, Véronique, Gonelle-Gispert, Carmen, Yung, Gisella Puga, Ehirchiou, Driss, Wyss, Jean-Christophe, Bigenzahn, Sinda, Irla, Magali, Heusser, Christoph, Golshayan, Déla, Seebach, Jörg D., Wekerle, Thomas, Bühler, Leo H.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859949/
https://ncbi.nlm.nih.gov/pubmed/20436684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010352
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