Inactivation of the von Hippel-Lindau tumor suppressor leads to selective expression of a human endogenous retrovirus in kidney cancer

A human endogenous retrovirus type E was recently found to be selectively expressed in most renal cell carcinomas (RCC). Importantly, antigens derived from this provirus are immunogenic, stimulating cytotoxic T-cells that kill RCC cells in vitro and in vivo. Here we show HERV-E expression is restric...

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Detalhes bibliográficos
Main Authors: Cherkasova, Elena, Malinzak, Elizabeth, Rao, Sheila, Takahashi, Yoshiyuki, Senchenko, Vera N., Kudryavtseva, Anna V., Nickerson, Michael L., Merino, Maria, Hong, Julie A., Schrump, David S., Srinivasan, Ramaprasad, Linehan, W. Marston, Tian, Xin, Lerman, Michael I., Childs, Richard W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161150/
https://ncbi.nlm.nih.gov/pubmed/21602888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.179
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