Stops making sense: translational trade-offs and stop codon reassignment

BACKGROUND: Efficient gene expression involves a trade-off between (i) premature termination of protein synthesis; and (ii) readthrough, where the ribosome fails to dissociate at the terminal stop. Sense codons that are similar in sequence to stop codons are more susceptible to nonsense mutation, an...

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Autores principales: Johnson, Louise J, Cotton, James A, Lichtenstein, Conrad P, Elgar, Greg S, Nichols, Richard A, Polly, p David, Le Comber, Steven C
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161013/
https://ncbi.nlm.nih.gov/pubmed/21801361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-11-227
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