Indoprofen Upregulates the Survival Motor Neuron Protein through a Cyclooxygenase-Independent Mechanism

Most patients with the pediatric neurodegenerative disease spinal muscular atrophy have a homozygous deletion of the survival motor neuron 1 (SMN1) gene, but retain one or more copies of the closely related SMN2gene. TheSMN2gene encodes the same protein (SMN) but produces it at a low efficiency comp...

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Hauptverfasser: Lunn, Mitchell R., Root, David E., Martino, Allison M., Flaherty, Stephen P., Kelley, Brian P., Coovert, Daniel D., Burghes, Arthur H., Man, Nguyen thi, Morris, Glenn E., Zhou, Jianhua, Androphy, Elliot J., Sumner, Charlotte J., Stockwell, Brent R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2004
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160629/
https://ncbi.nlm.nih.gov/pubmed/15555999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2004.08.024
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