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Native N-glycopeptide thioester synthesis through N→S acyl transfer

Peptide thioesters are important tools for the total synthesis of proteins using native chemical ligation (NCL). Preparation of glycopeptide thioesters, that enable the assembly of homogeneously glycosylated proteins, is complicated by the perceived fragile nature of the sugar moiety. Herein, we dem...

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Autors principals: Premdjee, Bhavesh, Adams, Anna L., Macmillan, Derek
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Science Ltd 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160546/
https://ncbi.nlm.nih.gov/pubmed/21676613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.05.059
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