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SOD1 overexpression in vivo blocks hyperglycemia-induced specific PKC isoforms-substrate activation and consequent lipidperoxidation in diabetic embryopathy
OBJECTIVE: Oxidative stress plays a causative role in diabetic embryopathy. We tested whether mitigating oxidative stress, using superoxide dismutase 1 (SOD1) transgenic mice, would block hyperglycemia-induced specific PKC isoform activation and its downstream cascade. STUDY DESIGN: Day 8.5 (E8.5) e...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3160525/ https://ncbi.nlm.nih.gov/pubmed/21529760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajog.2011.02.071 |
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