Shugoshin is a Mad1/Cdc20-like interactor of Mad2

Mammalian centromeric cohesin is protected from phosphorylation-dependent displacement in mitotic prophase by shugoshin-1 (Sgo1), while shugoshin-2 (Sgo2) protects cohesin from separase-dependent cleavage in meiosis I. In higher eukaryotes, progression and faithful execution of both mitosis and meio...

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Bibliographic Details
Main Authors: Orth, Michael, Mayer, Bernd, Rehm, Kinga, Rothweiler, Ulli, Heidmann, Doris, Holak, Tad A, Stemmann, Olaf
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160248/
https://ncbi.nlm.nih.gov/pubmed/21666598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.187
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