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Cytochrome P450 2C19 Polymorphism is Associated with Reduced Clopidogrel Response in Cerebrovascular Disease

PURPOSE: Clopidogrel is a prodrug that requires transformation into an active metabolite by cytochrome P450 (CYP) in the liver in order to irreversibly inhibit the P2Y12 adenosine diphosphate platelet receptor. CYP2C19 polymorphism has been reported to correlate with reduced antiplatelet activity of...

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Détails bibliographiques
Auteurs principaux: Lee, Jun-Beom, Lee, Kyung-A, Lee, Kyung-Yul
Format: Artigo
Langue:Inglês
Publié: Yonsei University College of Medicine 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159941/
https://ncbi.nlm.nih.gov/pubmed/21786436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3349/ymj.2011.52.5.734
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