Cytochrome P450 2C19 Polymorphism is Associated with Reduced Clopidogrel Response in Cerebrovascular Disease

PURPOSE: Clopidogrel is a prodrug that requires transformation into an active metabolite by cytochrome P450 (CYP) in the liver in order to irreversibly inhibit the P2Y12 adenosine diphosphate platelet receptor. CYP2C19 polymorphism has been reported to correlate with reduced antiplatelet activity of...

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Bibliografiska uppgifter
Huvudupphovsmän: Lee, Jun-Beom, Lee, Kyung-A, Lee, Kyung-Yul
Materialtyp: Artigo
Språk:Inglês
Publicerad: Yonsei University College of Medicine 2011
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159941/
https://ncbi.nlm.nih.gov/pubmed/21786436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3349/ymj.2011.52.5.734
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