Oligomeric Structure of the Chemokine CCL5/RANTES from NMR, MS, and SAXS Data

CCL5 (RANTES) is a pro-inflammatory chemokine known to activate leukocytes through its receptor, CCR5. Although the monomeric form of CCL5 is sufficient to cause cell migration in vitro, CCL5’s propensity for aggregation is essential for migration in vivo, T cell activation and apoptosis, and HIV en...

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Bibliographic Details
Main Authors: Wang, Xu, Watson, Caroline, Sharp, Joshua S., Handel, Tracy M., Prestegard, James H.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159919/
https://ncbi.nlm.nih.gov/pubmed/21827949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.06.001
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