Tolerance Induced by Apoptotic Antigen-Coupled Leukocytes is Induced by PD-L1(+), IL-10-Producing Splenic Macrophages and Maintained by Tregs

Antigen-specific tolerance is a highly desired therapy for immune-mediated diseases. Intravenous infusion of protein/peptide antigens linked to syngeneic splenic leukocytes with ethylene carbodiimide (Ag-SP) has been demonstrated to be a highly efficient method for inducing peripheral, antigen-speci...

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Detalhes bibliográficos
Main Authors: Getts, Daniel R., Turley, Danielle M., Smith, Cassandra E., Harp, Christopher T., McCarthy, Derrick, Feeney, Emma M., Getts, Meghann Teague, Martin, Aaron J., Luo, Xunrong, Terry, Rachael R., King, Nicholas J. C., Miller, Stephen D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159828/
https://ncbi.nlm.nih.gov/pubmed/21821796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1004175
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