Mycobacterium tuberculosis triggers host type I interferon signaling to regulate IL-1β production in human macrophages

Mycobacterium tuberculosis is a virulent intracellular pathogen that survives in macrophages even in the presence of an intact adaptive immune response. Type I interferons (IFN) have been shown to exacerbate tuberculosis in mice and to be associated with disease progression in infected humans. Never...

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Autors principals: Novikov, Aleksey, Cardone, Marco, Thompson, Robert, Shenderov, Kevin, Kirschman, Kevin D., Mayer-Barber, Katrin D, Myers, Timothy G., Rabin, Ronald L., Trinchieri, Giorgio, Sher, Alan, Feng, Carl G.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159798/
https://ncbi.nlm.nih.gov/pubmed/21784976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100926
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