A SOCS-1 Promoter Variant is Associated with Total Serum IgE Levels()

SOCS-1 is a critical regulator of multiple signaling pathways, including those activated by cytokines that regulate immunoglobulin heavy chain class switching to IgE. Analysis of mice with mutations in the SOCS-1 gene demonstrated that IgE levels increase with loss of SOCS-1 alleles. This suggested...

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Hauptverfasser: Mostecki, Justin, Cassel, Suzanne L., Klimecki, Walter T., Stern, Debra A., Knisz, Judit, Iwashita, Sachiyo, Graves, Penelope, Miller, Rachel L., van Peer, Maartje, Halonen, Marilyn, Martinez, Fernando D., Vercelli, Donata, Rothman, Paul B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159751/
https://ncbi.nlm.nih.gov/pubmed/21795592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902569
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