Increased VEGFR-2 Gene Copy Is Associated With Chemoresistance and Shorter Survival in Patients with Non-small Cell Lung Carcinoma Who Receive Adjuvant Chemotherapy

Vascular endothelial growth factor-2 (VEGFR-2 or KDR) is a known endothelial target also expressed in NSCLC tumor cells. We investigated the association between alterations in the KDR gene and clinical outcome in patients with resected NSCLC (n=248). KDR copy number gains (CNGs), measured by quantit...

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Main Authors: Yang, Fei, Tang, Ximing, Riquelme, Erick, Behrens, Carmen, Nilsson, Monique B., Giri, Uma, Varella-Garcia, Marileila, Byers, Lauren A., Lin, Heather Y., Wang, Jing, Raso, Maria G., Girard, Luc, Coombes, Kevin, Lee, J. Jack, Herbst, Roy S., Minna, John D., Heymach, John V., Wistuba, Ignacio I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159530/
https://ncbi.nlm.nih.gov/pubmed/21724587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2614
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