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Robust substrate profiling method reveals striking differences in specificities of serum and lung fluid proteases

Proteases are candidate biomarkers and therapeutic targets for many diseases. Sensitive and robust techniques are needed to quantify proteolytic activities within the complex biological milieu. We hypothesized that a combinatorial protease substrate library could be used effectively to identify simi...

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Detalhes bibliográficos
Main Authors: Watson, Douglas S., Jambunathan, Kalyani, Askew, David S., Kodukula, Krishna, Galande, Amit K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159512/
https://ncbi.nlm.nih.gov/pubmed/21806553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2144/000113717
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