Design, Synthesis and Biological Evaluation of Triazolo-pyrimidine Derivatives as Novel Inhibitors of Hepatitis B Virus Surface Antigen (HBsAg) Secretion

The high levels of hepatitis B virus (HBV) surface antigen (HBsAg)-bearing subviral particles in the serum of chronically infected individuals play an important role in suppressing HBV-specific immune response, and are only mildly affected by the current small molecule therapies. Thus, a therapy tha...

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Autores principales: Yu, Wenquan, Goddard, Cally, Clearfield, Elizabeth, Mills, Courtney, Xiao, Tong, Guo, Haitao, Morrey, John D., Motter, Neil E., Zhao, Kang, Block, Timothy M., Cuconati, Andrea, Xu, Xiaodong
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158247/
https://ncbi.nlm.nih.gov/pubmed/21786803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200696v
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