Wavelength dependence of ultraviolet radiation-induced DNA damage as determined by laser irradiation suggests that cyclobutane pyrimidine dimers are the principal DNA lesions produced by terrestrial sunlight

To elucidate the involvement of specific ultraviolet (UV) wavelengths in solar mutagenesis, we used a laser system to investigate the induction of DNA damage, both in the overall genome and at the nucleotide resolution level, in the genomic DNA of transgenic Big Blue mouse fibroblasts irradiated wit...

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Autores principales: Besaratinia, Ahmad, Yoon, Jae-in, Schroeder, Christi, Bradforth, Stephen E., Cockburn, Myles, Pfeifer, Gerd P.
Formato: Artigo
Lenguaje:Inglês
Publicado: Federation of American Societies for Experimental Biology 2011
Materias:
Research Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157686/
https://ncbi.nlm.nih.gov/pubmed/21613571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-187336
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