ロード中...

Effects of Clinically Relevant MPL Mutations in the Transmembrane Domain Revealed at the Atomic Level through Computational Modeling

BACKGROUND: Mutations in the thrombopoietin receptor (MPL) may activate relevant pathways and lead to chronic myeloproliferative neoplasms (MPNs). The mechanisms of MPL activation remain elusive because of a lack of experimental structures. Modern computational biology techniques were utilized to ex...

詳細記述

保存先:
書誌詳細
主要な著者: Lee, Tai-Sung, Kantarjian, Hagop, Ma, Wanlong, Yeh, Chen-Hsiung, Giles, Francis, Albitar, Maher
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157383/
https://ncbi.nlm.nih.gov/pubmed/21858098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023396
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!