Plasma L-Cystine/L-Glutamate Imbalance Increases Tumor Necrosis Factor-Alpha from CD14+ Circulating Monocytes in Patients with Advanced Cirrhosis

BACKGROUND AND AIMS: The innate immune cells can not normally respond to the pathogen in patients with decompensated cirrhosis. Previous studies reported that antigen-presenting cells take up L-Cystine (L-Cys) and secrete substantial amounts of L-Glutamate (L-Glu) via the transport system Xc- (4F2hc...

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Detalhes bibliográficos
Main Authors: Kakazu, Eiji, Ueno, Yoshiyuki, Kondo, Yasuteru, Inoue, Jun, Ninomiya, Masashi, Kimura, Osamu, Wakui, Yuta, Fukushima, Koji, Tamai, Keiichi, Shimosegawa, Tooru
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157377/
https://ncbi.nlm.nih.gov/pubmed/21858100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023402
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