Human RAD18 Interacts with Ubiquitylated Chromatin Components and Facilitates RAD9 Recruitment to DNA Double Strand Breaks

RAD18 is an ubiquitin ligase involved in replicative damage bypass and DNA double-strand break (DSB) repair processes. We found that RPA is required for the dynamic pattern of RAD18 localization during the cell cycle, and for accumulation of RAD18 at sites of γ-irradiation-induced DNA damage. In add...

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Main Authors: Inagaki, Akiko, Sleddens-Linkels, Esther, van Cappellen, Wiggert A., Hibbert, Richard G., Sixma, Titia K., Hoeijmakers, Jan H. J., Grootegoed, J. Anton, Baarends, Willy M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157352/
https://ncbi.nlm.nih.gov/pubmed/21858012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023155
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