Matrix Metalloproteinase-2 and -9 Secreted by Leukemic Cells Increase the Permeability of Blood-Brain Barrier by Disrupting Tight Junction Proteins

Central nervous system (CNS) involvement remains an important cause of morbidity and mortality in acute leukemia, the mechanisms of leukemic cell infiltration into the CNS have not yet been elucidated. The blood-brain barrier (BBB) makes CNS become a refugee to leukemic cells and serves as a resourc...

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Detalhes bibliográficos
Main Authors: Feng, Saran, Cen, Jiannong, Huang, Yihong, Shen, Hongjie, Yao, Li, Wang, Yuanyuan, Chen, Zixing
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157343/
https://ncbi.nlm.nih.gov/pubmed/21857898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020599
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