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Enzyme Inhibition by Allosteric Capture of an Inactive Conformation
All members of the human herpesvirus protease family are active as weakly associating dimers, but inactive as monomers. A small molecule allosteric inhibitor of Kaposi’s sarcoma-associated herpesvirus protease (KSHV Pr) traps the enzyme in an inactive monomeric state where the C-terminal helices are...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3157250/ https://ncbi.nlm.nih.gov/pubmed/21723875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.06.032 |
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