Overexpression of Pyruvate Dehydrogenase Kinase 3 Increases Drug Resistance and Early Recurrence in Colon Cancer

The switch of cellular metabolism from mitochondrial respiration to glycolysis is the hallmark of cancer cells and is associated with tumor malignancy. Pyruvate dehydrogenase kinase-1 (PDK1) and PDK3 participate in the metabolic switch of cancer cells; however, the medical significance of PDK1 and P...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Lu, Chun-Wun, Lin, Shau-Chieh, Chien, Chun-Wei, Lin, Shih-Chieh, Lee, Chung-Ta, Lin, Bo-Wen, Lee, Jenq-Chang, Tsai, Shaw-Jenq
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 2011
Sujets:
Regular Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157210/
https://ncbi.nlm.nih.gov/pubmed/21763680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.05.050
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