Loss of Muscarinic M(1) Receptor Exacerbates Alzheimer's Disease–Like Pathology and Cognitive Decline

Alzheimer's disease (AD) is pathologically characterized by tau-laden neurofibrillary tangles and β-amyloid deposits. Dysregulation of cholinergic neurotransmission has been implicated in AD pathogenesis, contributing to the associated memory impairments; yet, the exact mechanisms remain to be...

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Detalhes bibliográficos
Main Authors: Medeiros, Rodrigo, Kitazawa, Masashi, Caccamo, Antonella, Baglietto-Vargas, David, Estrada-Hernandez, Tatiana, Cribbs, David H., Fisher, Avraham, LaFerla, Frank M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157199/
https://ncbi.nlm.nih.gov/pubmed/21704011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.04.041
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