Interactive effects of fatty acid and butyrate-induced mitochondrial Ca(2+) loading and apoptosis in colonocytes

BACKGROUND: The combination of fish oil-derived docosahexaenoic acid (DHA, 22:6, n-3) and butyrate (4:0), a fiber fermentation product, synergize to enhance colonocyte apoptosis by inducing a p53-independent, oxidation sensitive, mitochondrial Ca(2+-)dependent (intrinsic) pathway. METHODS: In this s...

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Main Authors: Kolar, Satya, Barhoumi, Rola, Jones, Chris K., Wesley, Joshua, Lupton, Joanne R., Fan, Yang-Yi, Chapkin, Robert S.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156959/
https://ncbi.nlm.nih.gov/pubmed/21563175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.26205
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