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Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise

BACKGROUND: Inbred individuals reared in controlled environments display considerable variance in many complex traits but the underlying cause of this intangible variation has been an enigma. Here we show that two modifiers of epigenetic gene silencing play a critical role in the process. RESULTS: I...

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Detalhes bibliográficos
Main Authors: Whitelaw, Nadia C, Chong, Suyinn, Morgan, Daniel K, Nestor, Colm, Bruxner, Timothy J, Ashe, Alyson, Lambley, Eleanore, Meehan, Richard, Whitelaw, Emma
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156950/
https://ncbi.nlm.nih.gov/pubmed/21092094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2010-11-11-r111
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