Extracellular Calcium Reduction Strongly Increases the Lytic Capacity of Pneumolysin From Streptococcus Pneumoniae in Brain Tissue

Background. Streptococcus pneumoniae causes serious diseases such as pneumonia and meningitis. Its major pathogenic factor is the cholesterol-dependent cytolysin pneumolysin, which produces lytic pores at high concentrations. At low concentrations, it has other effects, including induction of apopto...

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Detalhes bibliográficos
Main Authors: Wippel, Carolin, Förtsch, Christina, Hupp, Sabrina, Maier, Elke, Benz, Roland, Ma, Jiangtao, Mitchell, Timothy J., Iliev, Asparouh I.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156923/
https://ncbi.nlm.nih.gov/pubmed/21849290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jir434
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